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Information about Sustiva (Efavirenz) Sustiva is a prescription medication that contains efavirenz, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV (human immunodeficiency virus) infection. It works by blocking the action of reverse transcriptase, an enzyme critical for HIV replication. Visit the U.S. Food and Drug Administration's BeSafeRx campaign page for information on how to safely buy prescription medicines online and to locate a state-licensed online pharmacy. You can also contact your state board of pharmacy to verify a pharmacy's license. Ways to save on generic Sustiva These programs and tips can help make your prescription more affordable Lower Cost Alternative Less expensive drugs that work the same way may be available. The U.S. Food and Drug Administration warns that there are online pharmacies that claim to sell prescription drugs at deeply discounted prices, often without requiring a prescription. 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