About Diflucan Generic fluconazole (Diflucan) is an inexpensive drug used to treat or prevent certain kinds of fungal or yeast infections. It is more popular than comparable drugs. It is available in generic and brand versions. Generic fluconazole is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be … About fluconazole Generic fluconazole (Diflucan) is an inexpensive drug used to treat or prevent certain kinds of fungal or yeast infections. It is more popular than comparable drugs. It is available in generic and brand versions. Generic fluconazole is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may … Compare fluconazole prices, print discount coupons, find manufacturer promotions, copay cards and patient assistance programs. How much does fluconazole (diflucan) cost? $10-$80 without insurance, $0-$25 with insurance. Full cost breakdown, insurance coverage, and how to save. 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