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Order SUSTIVA, TAB 600MG (30/BT) by MCKESSON PHARMAC 00056051030 Active Ingredient: Efavirenz Mechanism of Action: Sustiva works by inhibiting the reverse transcriptase enzyme, preventing the replication of the HIV virus. Approved Uses: Sustiva is approved for use in adults, adolescents, and children six months of age and older who weigh at least 3.5 kg. It is used in combination with other antiretroviral drugs as part of a comprehensive treatment plan for … It helps to decrease the amount of HIV in your body so your immune system can work better. This lowers your chance of getting HIV complications (such as new infections, cancer) and improves your quality of life. Efavirenz belongs to a class of drugs known as non-nucleoside reverse transcriptase inhibitors (NNRTIs). 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